Tretizen 10 acts due to the active type of vitamin A, which has increased synthesis in the human body. Isotretinoin is actively synthesized into the form of tretinoin and similar transformations of nuclear ligands, which change gene expression and protein synthesis (induction or types of inhibition), which depends on the degree of tissue damage.
Tretizen 10 reduces the activity and sebaceous glands, which leads to a decrease in Propionibacterium acnes, which Isotretinoin cannot provide by itself. The drug has a complex antibacterial action. The drug is an excellent anti-inflammatory agent with an antiseptic effect, which reduces the external signs of seborrhea and slows down the temperature differentiation of keratinocytes. With regular use accelerates the process of regeneration of skin tissue cells.
Tretizen 10 is used in various forms of acne or acne, including the treatment of abscess diseases, as well as hemorrhagic, draining, and prone to the formation of scars, acne and acne. The drug works when standard therapy methods are contraindicated. The drug is prescribed as part of the complex treatment of rosacea, severe forms of folliculitis, caused by the action of pathogenic m / o, as well as purulent hydradenitis (with additional treatment). The drug is also productive in the treatment of dysfunctions of horny tissues, roaccutane (isotretinoin) price is available for a course of treatment
Contraindications to Tretizen 10 mg:
Tretizen 10 for acne is contraindicated with high sensitivity to the ingredients of the drug, during pregnancy and lactation (the drug has an embryotoxic effect). In the presence of vitamin A hypervitaminosis, it is also forbidden to use the remedy. The rectal form of the drug is not recommended for use in diseases of the rectum. Various kinds of metabolic disorders (familial form of the disease, all forms of alcoholism, obesity disease, diabetes mellitus). The active substance Isotretinoin increases the concentration of triglyceride in the body, which leads to an increased risk of cardiovascular dysfunction. The drug is not used for liver disease, renal failure, chronic pancreatic disease, diabetes, or susceptibility to it.
Tretizen 10 for acne should be taken immediately before or after a meal. In the treatment of acne vulgaris, the dose per day is 0.5 mg per kg of body weight. The course of treatment is 1-2 doses per day for 2-4 weeks. After that, the dose should be doubled and continue treatment for another 10-20 weeks. The highest daily dosage is 2 mg / kg. The dose may be adjusted depending on the personal tolerance of the drug and the presence / absence of adverse events. Usually, visible improvement can be achieved after the first month of regular use of the drug.
Clinical remission occurs after 4-5 months of treatment of diseases. A significant reduction in acne by 70 percent or more is considered effective. In the case of recurrence of the disease, the treatment pauses at 7-8 weeks, after which the course should be resumed. In case of exacerbation of the disease, the dosage of the drug should be halved by 2 weeks. In the case of clinical remission, the dosage of the drug is reduced.